A Symposium on Mechanisms of Toxicity by W. N. Aldridge (eds.)

By W. N. Aldridge (eds.)

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Even the earlier results had already elicited some doubt about the sole responsibility of the tail circulation for the hypothermia, because of the reduced ability of the poisoned rats to withstand exposure to cold. Anticholinesterases in Hypothermia 37 Piloerection . 8 No. of animals 6 .. "' ·§ \ 4 •2: ~2 26 f 0 I -4 I -3 I -2 I -1 I 0 I 2 I 3 I 4 I 5 Time (h) FIG. 6. Effect of cold-exposure (1 h at 20°C below room temperature) on the body temperature before and after the full development of a soman-hypothermia in a group of six rats.

Physiol. , HADDOW, J. , KIND, C. & CocKBURN, F. (1968). Metabolism, 17, 1094 KRIVOGLAZ, B. A. (1965). In Klinika i Lecheniye Intoksikatsiy, p. 32. , (February 1966), report 34, p. 180 LoMAX, P. & JENDEN, D. J. (1966). Int. J. , 5, 353 MEETER, E. (1969). Archs int. Pharmacodyn. , 182, 416 MEETER, E. & WoLTHUIS, 0. L. (1968). Eur. J. , 4, 18 MEETER, E. & WoLTHUIS, 0. L. (1969). Acta physiol. pharmac. , 15, 55 PREUSSER, H. J. (1967). Z. , 80, 436 Anticholinesterases in Hypothermia RAND, R. , BURTON, A.

It was therefore interesting to see whether ChE inhibitors have an influence on the tail circulation. When a rat is kept in a restraining cage at an environmental temperature of 22°-24°C with a thermistor inserted 6 em into the rectum and another attached halfway down the tail, the rectal temperature is usually between Soman +atropine So man 0 12 Time (h) FIG. 1. Lg/kg) at time 0, given during a brief hexobarbitone anaesthesia (17 mg/kg, intraperitoneally). Two groups of eight rats, one receiving atropine sulphate (50 mg/kg, intraperitoneally) a few minutes before the soman injection.

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