Abl Family Kinases in Development and Disease (Molecular by Anthony Koleske

By Anthony Koleske

Abl relatives Kinases in improvement and sickness presents an outline of the services of Abl kinfolk kinases in improvement and illness. This new name discusses the biochemical, genetic, and phone organic information that elucidate the mobile roles for those kinases in those approaches.

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Extra info for Abl Family Kinases in Development and Disease (Molecular Biology Intelligence Unit)

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Additional proteins and signaling events likely contribute to the adhesive responses mediated by Abl family kinases. Concluding Remarks and Future Challenges The findings discussed in this chapter clearly indicate that Abl family kinases are functionally relevant mediators of cellular responses to integrin engagement. During the early stages of cell spreading, integrins trigger the association of Abl family kinases with multiple focal adhesion proteins and elevate the kinase activities of Abl and Arg to promote the phosphorylation of several cytoskeletal regulatory proteins.

A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins. Mol Cell Biol 1993; 13(12):7587-7595. 35. Miller AL, W a n g Y, Mooseker MS et al. T h e Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion. J Cell Biol 2004; 165(3):407-419. 36. Woodring PJ, Meisenhelder J, Johnson SA et al. c-Abl phosphorylates D o k l to promote filopodia during cell spreading.

In this study, loss of Lasp-1 from focal adhesions was linked to increased apoptosis in response to stresses, suggesting that Abl promotes cell death partly by inhibiting an integrin-dependent survival pathway mediated by Lasp-1. 22 Abl Family Kinases in Development and Disease Together, these studies indicate that integrins modulate the interactions of Abl family kinases with multiple proteins that regulate focal adhesion signaling and cytoskeletal dynamics. It should be noted that these identified interactions represent only a few pieces to a complex puzzle.

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