All About Albumin: Biochemistry, Genetics, and Medical by Theodore Peters Jr.

By Theodore Peters Jr.

The 1st of its style, All approximately Albumin summarizes the chemistry, genetics, metabolism, medical implications, and advertisement features of albumin. It offers the main up to date sequences, constructions, and compositions of many species, and comprises greater than 2000 references.

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Extra info for All About Albumin: Biochemistry, Genetics, and Medical Applications

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With this "breathing" action, and with many of its amino acid side chains constantly in motion on a micro scale, the albumin molecule is well fitted to assimilate or release the many substances that it transports in the circulation. II. Tertiary Structure and Physical Chemical Behavior 39 B. Physical C h e m i s t r y In this section we will consider the physicochemical properties of human and bovine serum albumins, especially as they can furnish information on the behavior of various chemical groups within the albumin molecule in relation to the tertiary structure.

Stereo ball-stick model of the structure around residue CySH-34 of HSA. Red, oxygen; yellow, carbon; blue, nitrogen; green, sulfur. From Carter and Ho (1994) with permission of Academic Press. ] 34 2. Albumin Molecule: Structure and Chemistry I0 I0, l 2 2[b"] I~i ~ I t~ I~1 ['~6 T ~ 4 F b 6 P I 8 II I0 IA IB IIA IlIA lib ~ I IIIB I II. Tertiary Structure and Physical Chemical Behavior 35 apparently becomes more compact, the molecule resists proteolytic degradation and heat denaturation, the dielectric constant falls, and bilirubin binding is enhanced.

2 ,~ from Tyr-411" X-ray diffraction found a greater distance, ~36 ]k, which He and Carter (1992) conjectured may be due to experimental error and lack of knowledge about the orientation of the fluorescent probe on Tyr-411 and the quencher on Cys-34. Unfortunately, the atomic coordinates of the He and Carter model have not been made public, so that the scientific community cannot make its own distance computations or other assessments. The general layout of the peptide chain within the crystal structure of Fig.

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