Amylin: Physiology and Pharmacology by Andrew Young

By Andrew Young

Deciphers amylin's body structure and divulges formerly unrecognized mechanisms basic to regulate bodyweight and gas homeostasis. additionally discusses healing software of amylin because the first new drugs to regard diabetes seeing that insulin.

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Diabetologia 37, 188–194. , and Pacini, G. (1996a). Beta‐cell activity and hepatic insulin extraction following dexamethasone administration in healthy subjects. Metab. Clin. Exp. 45, 486–491. , and Prager, R. (1996b). Elevated proinsulin and islet amyloid pancreatic polypeptide (IAPP) secretion in gestational diabetes. Diabetes 45, 174A. , and Lillioja, S. (1993). Use of a new two‐site immunoassay for amylin to characterize amylin hormone response in Pima Indians. Diabetologia 36, A137. Koda, J.

Clore, J. , and Kellum, J. M. (1994). Amylin/insulin secretory ratios in morbidly obese man: Inverse relationship with glucose disappearance rate. J. Clin. Endocrinol. Metab. 78, 1257–1260. Blase, E. , Koda, J. , and Phelps, J. L. Monoclonal antibody to the c‐terminal end of human amylin—used in assays for the detection of human amylin or amylin analogues. EP 408294; WO 9211863; WO 9216845. , Ghatei, M. , Bloom, S. , Ferrier, G. , Girgis, S. , and Legon, S. (1989). Altered islet amyloid polypeptide (amylin) gene expression in rat models of diabetes.

Van Mansfeld, A. , van Unnik, J. , Berends, M. , and Lips, C. J. (1992b). No constant relationship between islet amyloid polypeptide (IAPP) and insulin expression in insulinomas. Neth. J. Med. 41, 264–271. , and Nanjo, K. (1992). Lack of effect of islet amyloid polypeptide on hepatic glucose output in the in situ‐ perfused rat liver. Metabolism 41, 431–434. O’Brien, T. , and Johnson, K. H. (1991). Islet amyloid polypeptide and insulin secretion from isolated perfused pancreas of fed, fasted, glucose‐treated, and dexamethasone‐treated rats.

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