Annual Review of Gerontology and Geriatrics, Volume 10, by Vincent J. Cristofalo PhD

By Vincent J. Cristofalo PhD

This quantity offers a transparent, concise evaluation of the present country of data in regards to the biology of getting older ñ serving as either a useful graduate-level textual content and a key reference for practising execs. Over a dozen distinctive individuals probe the most recent advancements in our wisdom of why humans age and the way the method works. those authoritative chapters will not be simply written for biologists ñ yet for gerontologists as a rule. Marks the 10th anniversary of the yearly overview of Gerontology and Geriatrics.

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Overall, despite its appeal, the specific role of free radicals in aging will be difficult to define. The concept that free radicals represent a single basic cause of aging on which other aging changes depend is. I believe, unlikely to be correct. CELLULAR BASIS OF AGING Most of our discussion, thus far, has dealt with aging at the organism level. The cell is the fundamental living unit, however, and I would like to conclude with a discussion of aging at the cell level. From a historical viewpoint the concept of aging as a cell-based phenomenon is comparatively new.

The whole issue of proliferative homeostasis must be evaluated in terms of the ability of the organism to respond successfully through carefully regulated replication to environmental stress. Mechanistically, the aging of proliferating mesenchymal cells may be quite different from that of fixed postmitotic cells or reverting postmitotic cells. Perhaps these cells in culture are not significant in determining the life-span of the organism. It is not life-span but rather the mechanism regulating the process of aging that is of interest, however.

1981). Immunopathology of aging. In C. ), Annual Review of Gerontology and Geriatrics (Vol. 2, p. 3). New York: Springer Publishing Co. Wareham, V. , et al. (1987). Age related reactivation of an X-linked gene. Nature, 327, 725. 22 V. J. CRISTOFALO Warthin, A. S. (1929). Old age, the major revolution: The philosophy and pathology of the aging process. New York: Hoeber. Weissman, A. (1882). Uber die dauer des lebens. Jena, Germany. Williams, G. C. (1957). Pleiotropy, natural selection and the evolution of senescence.

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