Arachidonic Acid in Cell Signaling by Daniele Piomelli

By Daniele Piomelli

This ebook is set the arachidonic acid cascade, its biochemistry, its pharmacology, and its roles in sign transduction. Arachidonic acid may well function an intracellular moment messenger in lots of mobilephone varieties, in addition to precursor for biologically energetic molecules corresponding to the eicosanoids (a kinfolk of oxygenated metabolites which could act as moment messengers or as neighborhood mediators), and anandamide (an endogenous cannabinoid substance). Dysfunctions within the arachidonic acid cascade underlie a few severe pathological stipulations, making those biochemical pathways the objective for medications of scientific value.

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Cell by cell, and stimulus by stimulus) is essential to determine whether an observed biological action of exogenous arachidonate is likely to mimic that of an evoked physiological response. Moreover, arachidonate is poorly soluble in water: given the alternative, it will partition in lipid membranes 104 times more than in an aqueous phase. Thus, its actual concentration and its cellular sites of action will be dictated not only by the mass produced upon stimulation, but also by the presence of mechanisms of intracellular transport between membrane compartments.

Cell by cell, and stimulus by stimulus) is essential to determine whether an observed biological action of exogenous arachidonate is likely to mimic that of an evoked physiological response. Moreover, arachidonate is poorly soluble in water: given the alternative, it will partition in lipid membranes 104 times more than in an aqueous phase. Thus, its actual concentration and its cellular sites of action will be dictated not only by the mass produced upon stimulation, but also by the presence of mechanisms of intracellular transport between membrane compartments.

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