Bio-inspired regenerative medicine : materials, processes, by Anna Tampieri, Simone Sprio

By Anna Tampieri, Simone Sprio

This e-book provides a large and interdisciplinary evaluate of the present state-of-the-art within the improvement of biomimetic fabrics for tissue regeneration at the foundation of suitable and high-impact medical wishes. It particularly emphasizes the regeneration of bone, cartilage, and osteochondral tissues in addition to gentle tissues similar to nerves, middle, and endocrine organs. It brings jointly contributions from fabrics scientists, biologists, and surgeons with globally famous adventure within the box of regenerative medicine.

The goal of the e-book is to spotlight the relevance of biomimetics as an non-obligatory method for the advance of recent scaffolds that may direct regenerative cascade via chemico-physical and topological nano-cues awarded to cells and biologic tissues. fairly, the ebook refers to rising techniques in synthesis methods and scaffolds encouraged through nature in addition to to novel ways for shrewdpermanent functionalization akin to using magnetic signaling.

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77. , S. Samanta, and A. Chaudhuri, Cationic amphiphiles: Promising carriers of genetic materials in gene therapy. Chemical Society Reviews, 2009. 38(12), pp. 3326–3338. 78. , Nanotechnologies and regenerative medical approaches for space and terrestrial medicine. Aviation, Space, and Environmental Medicine, 2012. 83(11), pp. 1025–1036. 79. , Inorganic nanomaterials as delivery systems for proteins, peptides, DNA, and siRNA. Current Opinion in Colloid & Interface Science, 2013. 18(5), pp. 468–480.

Thus, GFs release has to be precisely controlled. A plethora of nanostructured particulate technologies have been developed, aiming at delivering proteins [74], peptides [75], drugs [76], and genetic materials [77], in a controlled fashion in the site to be regenerated [71, 78, 79]. 1 Polymeric vectors Polymeric materials are frequently used to allow controlled, sustained, and localized delivery of proteins. Polymer delivery vehicles allow to control the kinetics and dose of protein release while also protecting the protein from degradation until release [71].

9(3), pp. 5431–5437. 30. Anderson, J. , Biological responses to materials. Annual Review of Materials Research, 2001. 31(1), pp. 81–110. 31. , and J. Anderson, Protein and surface effects on monocyte and macrophage adhesion, maturation, and survival. Journal of Biomedical Materials Research, 2002. 60(3), pp. 487–496. 32. , Effects of adsorbed proteins and surface chemistry on foreign body giant cell formation, tumor necrosis factor alpha release and procoagulant activity of monocytes. Journal of Biomedical Materials Research Part A, 2004.

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