Biomedical Applications of Polyurethanes (Tissue Engineering by Patrick Vermette

By Patrick Vermette

The authors of this booklet speak about polyurethanes utilized in a number of biomedical functions. Polyurethanes shape a wide kin of polymeric fabrics with a tremendous range of chemical compositions and houses the wide variety of homes that may be completed with polyurethane chemistry has attracted the eye of builders of biomedical units who see promise within the mechanical flexibility of those fabrics mixed with their excessive tear power.

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When using extrusion techniques, care must be given to the temperature since PUs can degrade due to long residence time of the polymer into the extruder. While extrusion is the primary choice for making tubing, solvent methods can also be very suitable in order to produce nonporous tubings. Generally, tubings are produced onto a polymer mandrel (usually polyethylene or polyvinylchloride-based materials) which becomes part of the tubing or onto a metal mandrel which is removed later on. Particular attention must be given in order to completely remove residual solvent, which can directly affect the performance of the end-use products.

110 Again the use of additives should be carefully justified. 5 Mrads). 5 Mrads is sufficient to kill most microbes. Lower doses will have fewer negative effects like discoloration and embrittlement. The emission of gamma rays is usually obtained from cobalt 60 but cesium 137 may also be used. Materials exposed to cobalt 60 or cesium 137 will not be radioactive after the sterilization because gamma rays have no mass. The accuracy of gamma-ray sterilization is independent of the thickness or the density of the materials.

Which was a polyurethane/silicone hybrid. In 1972, Biomer™, a version of Lycra® T-126 produced by Ethicon Corp. ) under a license from DuPont was made available. , by dipping, spraying or casting, and are not extrudable or moldable. Nevertheless, as the first “real” biomedical polyurethanes, these two polymers were studied intensively. 28,39-45 Avcothane™ was used clinically in the first intra-aortic balloon pump (IAB) starting in about 1971. ). 17 Avcothane™ and Biomer™ appeared at that time to possess a combination of thromboresistance, biostability and flex life that was sorely needed to make cardiac assist devices safe and efficacious.

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