Blood Science: Principles and Pathology by Andrew Blann, Nessar Ahmed

By Andrew Blann, Nessar Ahmed

lood technology is a comparatively new self-discipline which merges biochemistry, haematology, immunology, transfusion technology and genetics. This bringing jointly of conventional disciplines calls for a corresponding swap in schooling and coaching for healthcare scientists and Blood technology: rules and Pathology is written in line with this rising need.
 
An creation to the topic and an outline of the innovations utilized in blood technological know-how are through a chain of chapters in response to teams of analytes investigated in blood - purple blood cells, white blood cells and platelets, through the materials of plasma, together with waste items, electrolytes, glucose, lipids, enzymes, hormones, foodstuff, medications, poisons and others.
 
Each bankruptcy is supported by way of studying ambitions, summaries and additional info, and a spotlight is given to bankruptcy particular case stories with interpretation to illustrate how laboratory information together with medical info is utilised while investigating sufferers with genuine or suspected ailment. eventually, a separate bankruptcy deals extra unique case studies that combine different points of blood science.
 
Undergraduate scholars taking blood technological know-how modules as a part of their BSc programmes in Biomedical and Healthcare Sciences will delight in the extent of integration among medical biochemistry and haematology. furthermore, this booklet will offer compatible preliminary examining for these scholars embarking on blood technological know-how modules on MSc programmes and may be of price to new graduates coming into the career and beginning their profession in blood technological know-how departments via supplementing practice-based education with the necessary theoretical underpinning.
Blood technology is a comparatively new self-discipline which merges biochemistry, haematology, immunology, transfusion technology and genetics. This bringing jointly of conventional disciplines calls for a corresponding switch in schooling and coaching for healthcare scientists and Blood technological know-how: ideas and Pathology is written in keeping with this rising need.
 
An advent to the topic and an summary of the innovations utilized in blood technology are by way of a sequence of chapters in accordance with teams of analytes investigated in blood - purple blood cells, white blood cells and platelets, by way of the ingredients of plasma, together with waste items, electrolytes, glucose, lipids, enzymes, hormones, nutrition, medicines, poisons and others.
 
Each bankruptcy is supported by way of studying goals, summaries and extra details, and attention is given to bankruptcy particular case experiences with interpretation to illustrate how laboratory information along side medical info is utilised while investigating sufferers with genuine or suspected affliction. ultimately, a separate bankruptcy deals extra precise case stories that combine different features of blood science.
 
Undergraduate scholars taking blood technological know-how modules as a part of their BSc programmes in Biomedical and Healthcare Sciences will relish the extent of integration among scientific biochemistry and haematology. furthermore, this e-book will supply appropriate preliminary analyzing for these scholars embarking on blood technological know-how modules on MSc programmes and may be of price to new graduates coming into the occupation and beginning their profession in blood technology departments by way of supplementing practice-based education with the necessary theoretical underpinning.
 
This booklet is approved by means of the Institute of Biomedical technology and written via its specialist writers, lots of whom paintings at the Institute’s advisory panels.

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Extra info for Blood Science: Principles and Pathology

Example text

Almost all congenital disease (present at birth or noted in the immediate neonatal period) is genetic, and in some cases will need to be formally confirmed with molecular genetics. 4. Non-genetic congenital diseases will generally have been acquired from the mother, and these are generally metabolic and infectious diseases, such as some types of diabetes, HIV infection and syphilis. Others may be caused by drugs taken during pregnancy, such as thalidomide and warfarin, or perhaps by lack of adequate nutrition, such as the relationship between folic acid and neural tube defects.

Group AB people have no anti-A or anti-B antibodies in their plasma, but group O people have both anti-A and anti-B antibodies. 3. The second most important blood group system is the rhesus (Rh) system. It is very much more complicated, being composed of over 40 recognized glycoproteins, although on a day-to-day basis five different structures on the surface of the blood cell are commonly dealt with in the blood bank. e. RhD). 3 ABO blood group factors. Antigenic structures on the red cell surface Antibodies in the plasma A B AB O Anti-B Anti-A No antibodies Anti-A and Anti-B between the ABO and Rh systems is that, in the normal person, there are always anti-A and anti-B antibodies in the absence of reciprocal molecules on the red blood cell surface (which makes ABO incompatibility potentially fatal), but people with the D molecule on the red cell surface do not have a corresponding antibody in the plasma.

The preceding section has introduced the value of genetics in many different types of diseases, including cancer. Indeed, it could be argued that clinical genetics is in fact a collection of methods called on by pathologists to help with diagnosis. Accordingly, this textbook will not have a separate chapter on genetics. Instead, each individual chapter will emphasize genetics where and when it is appropriate. Examples of the impact of genetics in the other blood sciences include:  haemoglobinopathy, leukaemia, haemophilia, von Willebrand’s disease, Factor V Leiden, and hereditary haemochromatosis in haematology;  alpha-1-trypsin deficiency, LDL cholesterol receptor, cystic fibrosis and 21-hydroxylase deficiency in biochemistry;  ABO and rhesus blood groups in transfusion science;  the heritability of autoimmune disease, X-linked agammaglobuminaemia, variation in human leukocyte antigens (HLAs), and DiGeorge syndrome in immunology.

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