By Connie Henke Yarbro, Debra Wujcik, Barbara Holmes Gobel
A brand new and revised model of this best-selling reference! For over eighteen years, best-selling melanoma Nursing: rules and perform has supplied oncology nurses with the most recent info on new developments within the swiftly altering technology of oncology. Now, in its 7th variation, melanoma Nursing has been thoroughly revised and up to date to mirror key new advancements. New themes coated contain specified remedy, allergic reaction reactions, mucositis, and relatives and caregiver concerns. With 27 new chapters that includes insights from key authors, the 7th variation is a must have source for each oncology nurse.
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Extra info for Cancer Nursing: Principles and Practice (7th Edition)
Chronic insults may produce genetic mutations that cause cancer. Epigenetics Cancer can be caused by factors that do not alter the DNA nucleotide sequence. Epigenetic causes may include factors that alter the expression of genetic information at the transcriptional (eg, methylation), translational, and posttranslational (eg, micro RNA) levels. Oncogene hypothesis All cells have genes that are involved in cell proliferation and growth signaling pathways and mechanisms. Cancer may result from mutations to oncogenes and other mechanisms that lead to overactivity of these genes.
Second-generation transgenic mouse models exhibit conditional gene-mutation strategies. In the commonly used CrelloxP recombinase system, a tumor suppressor gene may be flanked by recombinase recognition loxP sites (the allele is said to be “floxed”), then the Cre recombinase is introduced by interbreeding with transgenic mice that have tissue-specific or drug-induced Cre. ”12 Conditional mouse models, along with improved fluorescence and bioluminescence imaging mechanisms that monitor tumor development, growth, and metastasis in living mice, help address complex questions in tumor biology.
Transformed cells do not require a solid substrate. Only tumor cells grow in soft agar (no anchorage); cell growth in soft agar highly correlates with tumorigenicity. Loss of cell cycle control Cell does not progress normally through cell cycle pathways and checkpoints. ) Reduced apoptosis Cancer cells are less susceptible to programmed death. ) New surface antigens Cancer and transformed cells exhibit new molecules on the surface. Viruses can transform and alter multiple cell surface antigens.