Cardiac Energy Metabolism in Health and Disease by Gary D. Lopaschuk, Naranjan S. Dhalla

By Gary D. Lopaschuk, Naranjan S. Dhalla

The center has a truly excessive power call for yet little or no power reserves. so as to maintain contractile functionality, the center has to continually produce a large number of ATP. the guts makes use of loose fatty acids in general and carbohydrates to some degree as substrates for making strength and any switch during this power offer can heavily compromise cardiac functionality. It has emerged that adjustments in cardiac power metabolism are a big contributor to the advance of a few assorted types of middle sickness. it's also referred to now that optimizing power metabolism within the middle is a doable and demanding method of treating numerous kinds of center disease.

Cardiac strength Metabolism in future health and Disease describes the study advances which were made in figuring out what controls cardiac strength metabolism at molecular, transcriptional and physiological degrees. It additionally describes how adjustments in power metabolism give a contribution to the advance of center disorder and the way optimization of power metabolism can be utilized to regard center sickness. the subjects coated contain a dialogue of the consequences of myocardial ischemia, diabetes, weight problems, hypertrophy, middle failure, and genetic issues of mitochondrial oxidative metabolism on cardiac energetics. The remedy of middle ailment via optimizing strength metabolism can be mentioned, together with expanding total strength construction in addition to expanding the potency of power construction and switching power substrate choice of the center. This booklet should be a worthy resource of knowledge to graduate scholars, postdoctoral fellows, and investigators within the box of experimental cardiology in addition to biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and different overall healthiness professionals.

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Heather LC, Howell NJ, Emmanuel Y et al (2011) Changes in cardiac substrate transporters and metabolic proteins mirror the metabolic shift in patients with aortic stenosis. PLoS One 6:e26326 107. Steinbusch LK, Luiken JJ, Vlasblom R et al (2011) Absence of fatty acid transporter CD36 protects against Western-type diet-related cardiac dysfunction following pressure overload in mice. Am J Physiol Endocrinol Metab 301:E618–E627 108. Barger PM, Brandt JM, Leone TC et al (2000) Deactivation of peroxisome proliferatoractivated receptor-alpha during cardiac hypertrophic growth.

Circulation 115:3213–3223 129. Wende AR, Abel ED (2010) Lipotoxicity in the heart. Biochim Biophys Acta 1801: 311–319 130. Niu YG, Evans RD (2008) Metabolism of very-low-density lipoprotein and chylomicrons by streptozotocin-induced diabetic rat heart: effects of diabetes and lipoprotein preference. Am J Physiol Endocrinol Metab 295:E1106–E1116 131. Sambandam N, Abrahani MA, Craig S et al (2000) Metabolism of VLDL is increased in streptozotocin-induced diabetic rat hearts. Am J Physiol Heart Circ Physiol 278: H1874–H1882 132.

1 Substrate utilization by the heart. Glucose entry into cardiomyocytes occurs through transporters. Once inside, it undergoes glycolysis and pyruvate is formed, which is transported into the mitochondria. At this location, pyruvate undergoes decarboxylation to acetyl-CoA, which is eventually used for ATP generation. The other major substrate that is utilized by the heart is fatty acid (FA). FA is delivered to the heart from three major sources: (a) adipose tissue lipolysis with release of FA into the plasma, (b) LPL mediated breakdown of TG-rich lipoproteins from the liver (VLDL) and gut (chylomicron), and (c) endogenous triglyceride (TG) breakdown within the heart.

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