By Massimo Sabatini, Philippe Pastoureau, FrTdTric De Ceuninck
An crucial number of up-to-date classical and rising thoughts that promise so as to add severe wisdom to our knowing of cartilage metabolism in wellbeing and fitness and affliction. quantity 1: mobile and Molecular instruments describes confirmed molecular and mobile strategies for the in vitro learn of standard and osteoarthritic cartilage via biochemical, biomolecular, immunological, and actual ways, with emphasis at the genetic manipulation of cells. quantity 2: constitution and In Vivo research, bargains state of the art techniques for studies-at the tissue level-of turnover, constitution, and functioning of standard and diseased cartilage through invasive and noninvasive ability. entire and up to date, the 2 volumes of Cartilage and Osteoarthritis supply researchers and bench scientists with effortlessly reproducible protocols for brand new experiments to understand-from the mobile to the animal level-the pathophysiology of cartilage and to find molecular objectives for pharmacological intervention.
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Extra info for Cartilage and Osteoarthritis
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Robbins, J. , and Goldring, M. B. (2000) Proteoglycan production by immortalized human chondrocyte cell lines cultured under conditions that promote expression of the differentiated phenotype. Arch. Biochem. Biophys. 383, 79–90. Immortalized Chondrocyte Cell Lines 35 30. 30 Loeser, R. , and Goldring, M. B. (2000) Integrin expression by primary and immortalized human chondrocytes: evidence of a differential role for α1β1 and α2β1 integrins in mediating chondrocyte adhesion to types II and VI collagen.