Cholesterol Transporters of the START Domain Protein Family by Barbara J. Clark, Douglas M. Stocco

By Barbara J. Clark, Douglas M. Stocco

Non-vesicular intracellular ldl cholesterol delivery is a crucial mechanism for preserving membrane ldl cholesterol homeostasis. fresh experiences of reviews directed at soluble ldl cholesterol delivery proteins point out that aberrant expression of the beginning proteins might give a contribution to sickness states linked to issues in ldl cholesterol homeostasis. this is often a thrilling new course within the box and the aim of this booklet should be to spotlight the present study directed at power roles for the beginning relatives in diabetes, melanoma and atherogenesis.

This ebook additionally presents a private and ancient standpoint of the discovery-to-publication trip that the authors had for his or her specific begin area friend. The target could be to supply views to graduate scholars, post-doctoral fellows and endocrinology fellows at the learn discovery process.

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Additional info for Cholesterol Transporters of the START Domain Protein Family in Health and Disease: START Proteins - Structure and Function

Sample text

These results were published in Science in the spring of 1995 [55]. The human StAR mutation findings were corroborated in 1997 with the Proceedings of the National Academy of Sciences USA (PNAS) publication of the phenotype of the mouse StAR knockout by Keith Parker’s laboratory [56]. The mouse phenotype essentially mirrored the human phenotype and thus, a rodent lipoid CAH model became available for further study. Since that time, less severe mutations in the StAR gene as well as mutations in the CYP11A1 gene have been identified in patients with lipoid CAH [55, 57–59].

The facility indicated to us that approximately 100 pM would be required for sequencing and approximately twice this amount was sent to them. Tryptic digestion of the 30 kDa protein, high-performance liquid chromatography (HPLC) separation of digested protein into separate peaks and sequencing of three of these peaks produced sequences of 19, 13, and 12 amino acids. With this information, degenerative nucleotides of 17–24 bases long were 2 The Steroidogenic Acute Regulatory Protein (StAR) 21 synthesized and used to amplify the 30 kDa cDNA from a cDNA library using polymerase chain reaction (PCR).

This proximal promoter region of StAR has been most extensively studied utilizing mouse and human cell lines. These studies demonstrated that the conserved regulatory elements bind their cognate transcription factors in a cell-type- and species-specific manner. 4a). Zinc-Finger Transcription Factors Involved in StAR Gene Expression SF-1 is an orphan member of the nuclear receptor superfamily that binds as a monomer to the consensus DNA sequence, 5′- AGGTCA-3′; a sequence that was originally found to be common in promoters of several steroid hydroxylase genes [86–89].

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