By Marc A. Fritz MD, Leon Speroff MD
Validated for greater than thirty years as one of many world's most generally learn gynecology texts, scientific Gynecologic Endocrinology and Infertility is now in its 8th variation. In a transparent, hassle-free variety more advantageous via ample illustrations, algorithms, and tables, the ebook offers an entire rationalization of the feminine endocrine procedure and its problems and gives functional assistance on review and remedy of lady endocrine difficulties and infertility. significant sections hide reproductive body structure, scientific endocrinology, birth control and infertility. This version has a latest full-color design.A significant other web site comprises the absolutely searchable textual content, snapshot financial institution and hyperlinks to PubMed references.
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Extra resources for Clinical Gynecologic Endocrinology and Infertility, 8th Edition
Examples include the receptors for insulin and growth factors (tyrosine kinase) and the receptors for activin and inhibin (serine kinase). 52 The System of Internalization Receptors that do not fit the above categories include the receptors for LDL, prolactin, growth hormone, and some of the growth factors. These receptors allow entry of their ligands into cells by the process of endocytosis (discussed later in this chapter). Mechanism of Action for Steroid Hormones The specificity of the reaction of tissues to sex steroid hormones is due to the presence of intracellular receptor proteins.
Rapid cellular responses after estrogen stimulation are initiated by estrogen binding at the level of the cell wall membrane. These responses are traditionally associated with growth factors and G protein-coupled receptors. However, it is not appropriate to designate this activity as “nongenomic” because the cell membrane, estrogen-induced signaling, leads to both gene transcription and to events independent of transcription. 111 Putative membrane receptors have been reported to be both related to ER-a and different from the estrogen receptor.
If the cell is growing rapidly, about three newly assembled ribosomes will be transported every minute in the other direction. The typical cell can synthesize 10,000 to 20,000 different proteins. How do they know where to go? The answer is that these proteins have localization signals. In the case of steroid hormone receptor proteins, the signal sequences are in the hinge region. 54 Estrogen and progestin receptors exit continuously from the nucleus to the cytoplasm and are actively transported back to the nucleus.