Clinical Hepatology: Principles and Practice of by Henryk Dancygier

By Henryk Dancygier

Clinical Hepatology – ideas and perform of Hepatobiliary ailments presents transparent and complete insurance of the etiology, mechanisms of illness, prognosis, and functional administration of the full spectrum of liver and biliary problems. It additionally gives a good, evidence-based evaluation of the speedily increasing box of hepatobiliary diseases.

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The pericanalicular cytoplasm represents a specialized region of the hepatocyte that is responsible for the shape of the canaliculi. Actin filaments located in the pericanalicular ectoplasm radiate into the microvilli, suggesting that bile canaliculi are contractile structures that can actively “pump”, and thereby support bile transport. The canalicular bile drains into the periportal cholangioles, also called bile ductules, via the canals of Hering, which are located at the interface between the portal tract and lobular parenchyma.

G. acid phosphatase, aryl sulphatase, esterase, b-glucuronidase) which are involved in digestion of ingested macromolecules and turnover of intracellular components. Histochemically, lysosomes may be identified by demonstrating acid phosphatase. Lysosomes are part of the GERL-compartment (see Chapter 5). Lysosomes are involved in auto- and heterophagia. g. lipofuscin. These can stay for a long time inside the hepatocyte giving rise to so-called residual bodies. g. iron as ferritin • Uptake of clathrin-coated vesicles after receptor mediated endocytosis forming endosomes.

Both their number and their size vary according to their zonal localization. Mitochondria in perivenular zone 3 are smaller and more numerous than their counterparts in periportal zone 1. 20% of cytoplasmic volume of zone 3 hepatocytes falls upon mitochondria, while this fraction in zone 1 hepatocytes amounts to 13%. Mitochondria are bounded by a double membrane, separated by a slim intermembranous space. The outer membrane is permeable to substances with a molecular weight of up to 2 kDa. The inner membrane is highly folded to form shelves (cristae) which increase its surface area to nearly 30% of the total surface area of the cell membrane!

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