Cryptorchidism: Ultrastructure of Normal and Cryptorchid by F. Hadziselimovic

By F. Hadziselimovic

Cytological suggestions have vastly better within the final 20 years, mostly due to extra improvement of the microscope. Electron microscopy, specifically, has spread out nice clients for the learn of phone morphology, whereas the strengthen­ ment of radio-immuno-assay has introduced nice growth in endocrinology. The applica­ tion of those innovations, that are complementary to one another and supply at the same time assisting proof, is the topic of this monograph. The paintings is split into elements. the 1st bargains with the ultrastructure of standard testicular improvement, describing 4 major parts of the testicle - the germ cells, the Sertoli cells, the peri tubular connective tissue and the Leydig mobile- with info in their person improvement. To make the electron micrographs extra simply comprehensible, diagrams were used to give an explanation for an important issues. the second one half bargains with cryptorchid testicles, together with the first and sec­ ondary adjustments concerned and morphometric reviews of the secondary alterations. the importance of those ultrastructural observations for the remedy of cryptorchidism is emphasised. through radio-immuno-assay the extent of testosterone in cryp­ torchid mice was firm and comparisons drawn among the ultrastructural alterations in cryptorchidism in mouse and guy. The experimental experiences served as a foundation for the speculation that, most likely, a congenital disturbance of the hy­ pothalamo-hypophyso-gonadal axis is chargeable for cryptorchidism. i am hoping that this monograph will give a contribution in the direction of a greater realizing of ordinary and cryptorchid testicular improvement and of the etiology of cryptorchidism.

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Extra info for Cryptorchidism: Ultrastructure of Normal and Cryptorchid Testis Development

Example text

1973). They have an oval nucleus, with heterogenous chromatin situated mainly on the periphery, and loose reticular nucleoli. The most noticeable feature of the polygonal cytoplasm is the abundance of glycogen and ribosomes. The smooth endoplasmic reticulum is moderately well developed: rough endoplasmic reticulum is seldom encountered on the cell periphery (Fig. 38c). The lipoid droplets have a spherical form and lie mostly in groups, rarely singly, and are not in contact with the mitochondria.

38c, 39). The Leydig cells of cryptorchid mice whose mothers were treated with estrogen differ markedly from those of the control mice and those of the mice whose mothers received RCG and estrogen simultaneously (Fig. 38b). The cytoplasm is, on the whole, smaller, with a nucleus which is elliptical or fusiform rather than oval and exhibiting invaginations. The chromatin is distributed in groups, still lying mainly around the periphery. One to two loose reticular nucleoli lie on the periphery and form connections with the nuclear membrane.

In the vicinity of the concentric rows of smooth endoplasmic reticulum, there are many granules, 2500 A diameter, round or oval in shape and bounded by a membrane, with homogeneously dispersed electron-dense contents. An accumulation of these granules is also seen around the intercellular canalicules. The mitochondria are about I J1 in diameter, generally rod-shaped. They are of the crista type, but tubuli are also observed, some of them with intramitochondrial granules. The microvilli and mitochondria are in close contact.

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